PRPF38A

Across TCGA pan-cancer cohorts, PRPF38A mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated PRPF38A data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRPF38A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRPF38A expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where PRPF38A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.472	0.839	.004	36	view →
CCRCC	DFS	Tertile	All	0.854	0.977	.013	17	view →
GBM	OS	Tertile	All	0.662	0.288	.001	16	view →
LSCC	DFS	Tertile	All	0.870	0.323	.004	9	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
UCEC	DFS	Tertile	III,IV	0.376	0.880	.018	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LUAD	OS	Median	III,IV	0.808	0.299	.026	6	view →
OV	DFS	Median	All	1.000	0.702	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

PRPF38A–HNSC (DFS)

Open the HNSC breakdown →