PRPF38A

Across TCGA patient cohorts, PRPF38A mutation is significantly associated with the RNA expression of many other genes, with 2,897 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF38A-associated genes across cancer lineages are RNA5SP411, RNA5SP412, and RNU6-222P. Each is linked with PRPF38A in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF38A-to-partner and partner-to-PRPF38A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by PRPF38A-low versus PRPF38A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF38A→partner) and Y-score (partner→PRPF38A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.190	+2.715	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.476	+2.967	.002	<.001	3	2
BRCA	RNU6-222P →	+0.355	+6.268	<.001	.001	3	2
UCEC	RNA5SP413 →	+1.247	+2.277	<.001	.001	3	2
SKCM	RNU6-627P →	+0.333	+7.816	<.001	.008	3	1
SKCM	RNY4P28 →	+0.597	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,897 associations by consensus.

RNA5SP411 by PRPF38A expression — UCEC

Explore this box plot interactively →