PRPF38A

Across TCGA patient cohorts, PRPF38A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF38A-associated genes across cancer lineages are Notch1, PCNA, and Cyclin-B1. Each is linked with PRPF38A in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF38A-to-partner and partner-to-PRPF38A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PRPF38A-low versus PRPF38A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF38A→partner) and Y-score (partner→PRPF38A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.234	+2.807	<.001	.003	3	2
UCEC	PCNA →	+0.213	+2.115	.024	.019	3	2
UCEC	Cyclin-B1 →	+0.708	+2.807	.003	.003	3	2
UCEC	Myosin-IIa_pS1943 →	+0.252	+2.820	.005	.001	3	1
UCEC	p21 →	+0.193	+2.321	.021	.034	3	1
UCEC	AMPK_alpha →	-0.192	-2.999	.020	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by PRPF38A expression — UCEC

Explore this box plot interactively →