PRPF38A

Across TCGA cell cohorts, PRPF38A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,589 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRPF38A-associated GO terms across cancer lineages are DNA-templated DNA replication, Positive regulation of cell cycle process, and Negative regulation of G2/M transition of mitotic cell cycle. Each is linked with PRPF38A in more than 17 cancer types. Because this analysis shows association rather than direction, both PRPF38A-to-partner and partner-to-PRPF38A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by PRPF38A-low versus PRPF38A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF38A→partner) and Y-score (partner→PRPF38A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated DNA replication →	+0.162	+0.857	.001	.002	3	18
KIDNEY	Positive regulation of cell cycle process →	+0.077	+0.563	<.001	.002	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of G2/M transition of mitotic cell cycle →	+0.091	+0.999	<.001	<.001	3	17
BONE	DNA replication →	+0.146	+0.854	.001	.003	2	17
LIVER	DNA recombination →	+0.063	+0.751	.004	.004	3	16
SOFT_TISSUE	Mitotic spindle organization →	+0.079	+0.801	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,589 associations by consensus.

DNA-templated DNA replication by PRPF38A expression — BONE

Explore this box plot interactively →