PRPF31

Across TCGA patient cohorts, PRPF31 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,821 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PRPF31-associated proteins across cancer lineages are TRIM28, HSPBP1, and PRMT1. Each is linked with PRPF31 in more than 5 cancer types. Because this analysis shows association rather than direction, both PRPF31-to-partner and partner-to-PRPF31 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRPF31 versus TRIM28 in LSCC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF31→partner) and Y-score (partner→PRPF31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM28 →	+0.464	+0.555	<.001	<.001	3	6
OV	HSPBP1 →	+0.351	+0.469	.001	.002	3	6
LUAD	PRMT1 →	+0.375	+0.349	<.001	<.001	3	5
OV	PPP5C →	+0.480	+0.626	<.001	<.001	3	5
GBM	SAE1 →	+0.307	+0.334	<.001	<.001	3	5
GBM	DCTN5 →	-0.306	-0.351	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,821 associations by consensus.

PRPF31 vs TRIM28 — LSCC

Explore this scatter interactively →