PRPF31

Across TCGA patient cohorts, PRPF31 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF31-associated genes across cancer lineages are MEK1, mTOR_pS2448, and eIF4E. Each is linked with PRPF31 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF31-to-partner and partner-to-PRPF31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PRPF31-low versus PRPF31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF31→partner) and Y-score (partner→PRPF31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.423	+2.321	.004	.005	3	2
UCEC	mTOR_pS2448 →	-0.163	-2.308	.006	.033	3	2
UCEC	eIF4E →	+0.233	+3.335	.005	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-2.575	.025	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.184	-1.893	.006	.016	3	1
UCEC	Ku80 →	+0.306	+2.428	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MEK1 by PRPF31 expression — UCEC

Explore this box plot interactively →