PRPF31

Across TCGA cell cohorts, PRPF31 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,108 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRPF31-associated GO terms across cancer lineages are DNA replication, Microtubule cytoskeleton organization involved in mitosis, and Positive regulation of mitotic cytokinesis. Each is linked with PRPF31 in more than 16 cancer types. Because this analysis shows association rather than direction, both PRPF31-to-partner and partner-to-PRPF31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by PRPF31-low versus PRPF31-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF31→partner) and Y-score (partner→PRPF31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication →	+0.114	+0.756	.002	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Microtubule cytoskeleton organization involved in mitosis →	+0.109	+1.046	<.001	.001	3	15
SKIN	Positive regulation of mitotic cytokinesis →	+0.148	+0.811	<.001	<.001	3	15
BONE	Nucleic acid transport →	+0.103	+0.755	<.001	<.001	3	15
BONE	RNA transport →	+0.103	+0.755	<.001	<.001	3	15
BONE	DNA strand elongation involved in DNA replication →	+0.168	+0.613	.003	.004	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,108 associations by consensus.

DNA replication by PRPF31 expression — BONE

Explore this box plot interactively →