PRPF31

Across TCGA cell cohorts, PRPF31 mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRPF31-associated genes across cancer lineages are OPRPN, GCAT, and CBY1. Each is linked with PRPF31 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF31-to-partner and partner-to-PRPF31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by PRPF31-low versus PRPF31-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF31→partner) and Y-score (partner→PRPF31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OPRPN →	+0.993	+5.781	<.001	.001	3	1
LARGE_INTESTINE	GCAT →	+1.255	+3.364	.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.648	+3.307	<.001	.003	3	1
LARGE_INTESTINE	GAR1 →	+0.473	+3.169	.007	.009	3	1
LARGE_INTESTINE	KCNJ5 →	+0.687	+3.537	<.001	.001	3	1
LARGE_INTESTINE	RNF128 →	-2.136	-3.278	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

OPRPN by PRPF31 expression — BREAST

Explore this box plot interactively →