PRPF3

Across TCGA patient cohorts, PRPF3 mutation is significantly associated with the RNA expression of many other genes, with 806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF3-associated genes across cancer lineages are MED27, RBM15, and FBXO22. Each is linked with PRPF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF3-to-partner and partner-to-PRPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED27 grouped by PRPF3-low versus PRPF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF3→partner) and Y-score (partner→PRPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MED27 →	+0.441	+3.657	<.001	.001	3	2
UCEC	RBM15 →	+0.443	+2.923	<.001	<.001	3	2
UCEC	FBXO22 →	+0.438	+1.880	<.001	.005	3	2
UCEC	HINT1 →	+0.472	+3.000	.002	.001	3	2
UCEC	ZBTB8OS →	+0.382	+2.280	<.001	.001	3	2
UCEC	TIMM22 →	+0.376	+3.774	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 806 associations by consensus.

MED27 by PRPF3 expression — UCEC

Explore this box plot interactively →