PRPF3

Across TCGA cell cohorts, PRPF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,051 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PRPF3-associated GO terms across cancer lineages are Regulation of RNA splicing, Regulation of mRNA splicing, via spliceosome, and Regulation of mRNA processing. Each is linked with PRPF3 in more than 15 cancer types. Because this analysis shows association rather than direction, both PRPF3-to-partner and partner-to-PRPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by PRPF3-low versus PRPF3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF3→partner) and Y-score (partner→PRPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of RNA splicing →	+0.087	+1.067	<.001	<.001	3	16
BLOOD_Lymphoma	Regulation of mRNA splicing, via spliceosome →	+0.097	+1.201	<.001	<.001	3	16
OVARY	Regulation of mRNA processing →	+0.100	+0.919	<.001	<.001	3	16
BONE	Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) →	+0.130	+1.048	.004	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via homologous recombination →	+0.086	+1.076	.002	<.001	3	15
SOFT_TISSUE	Recombinational repair →	+0.074	+0.765	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,051 associations by consensus.

Regulation of RNA splicing by PRPF3 expression — BLOOD_Lymphoma

Explore this box plot interactively →