PRPF3

Across TCGA cell cohorts, PRPF3 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRPF3-associated genes across cancer lineages are SH3GL2, RASGEF1C, and CHSY3. Each is linked with PRPF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF3-to-partner and partner-to-PRPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by PRPF3-low versus PRPF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF3→partner) and Y-score (partner→PRPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.247	+3.252	.001	.009	3	1
LARGE_INTESTINE	RASGEF1C →	+0.226	+3.404	.002	.006	3	1
LARGE_INTESTINE	CHSY3 →	+0.548	+3.252	<.001	.009	3	1
LARGE_INTESTINE	USP17L7 →	+0.069	+3.013	<.001	.005	3	1
LARGE_INTESTINE	PTTG2 →	+0.075	+3.497	.002	.004	3	1
CNS	IL21 →	+0.028	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SH3GL2 by PRPF3 expression — LARGE_INTESTINE

Explore this box plot interactively →