PRPF19

Across TCGA patient cohorts, PRPF19 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF19-associated genes across cancer lineages are eIF4E, PTEN, and MEK1. Each is linked with PRPF19 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPF19-to-partner and partner-to-PRPF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PRPF19-low versus PRPF19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF19→partner) and Y-score (partner→PRPF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.184	+3.013	.039	.018	3	2
UCEC	PTEN →	-0.514	-3.169	.002	.019	2	3
UCEC	MEK1 →	+0.331	+2.459	.033	.019	3	1
UCEC	STAT3_pY705 →	-0.248	-1.700	.025	.044	3	1
UCEC	4E-BP1 →	+0.318	+2.199	.005	.033	3	1
UCEC	Rad50 →	-0.412	-4.000	<.001	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

eIF4E by PRPF19 expression — UCEC

Explore this box plot interactively →