PRPF19

Across TCGA cell cohorts, PRPF19 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,093 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRPF19-associated GO terms across cancer lineages are Positive regulation of attachment of mitotic spindle microtubules to kinetochore, Spindle elongation, and DNA replication initiation. Each is linked with PRPF19 in more than 16 cancer types. Because this analysis shows association rather than direction, both PRPF19-to-partner and partner-to-PRPF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of attachment of mitotic spindle microtubules to kinetochore grouped by PRPF19-low versus PRPF19-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF19→partner) and Y-score (partner→PRPF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.175	+0.610	<.001	.002	3	17
OVARY	Spindle elongation →	+0.247	+0.894	<.001	<.001	3	17
OVARY	DNA replication initiation →	+0.145	+0.790	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.253	+1.179	<.001	<.001	3	17
BREAST	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.150	+0.605	<.001	.002	3	16
KIDNEY	Mitotic spindle elongation →	+0.223	+0.860	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,093 associations by consensus.

Positive regulation of attachment of mitotic spindle microtubules to kinetochore by PRPF19 expression — BREAST

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