PRPF18

Across TCGA patient cohorts, PRPF18 mutation is significantly associated with the RNA expression of many other genes, with 866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF18-associated genes across cancer lineages are RN7SL840P, HNRNPH3P1, and IGHD6-6. Each is linked with PRPF18 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPF18-to-partner and partner-to-PRPF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL840P grouped by PRPF18-low versus PRPF18-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF18→partner) and Y-score (partner→PRPF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL840P →	+0.471	+3.068	<.001	.008	3	3
UCEC	HNRNPH3P1 →	+0.081	+2.018	.001	.002	3	3
HNSC	IGHD6-6 →	+1.478	+4.320	<.001	.007	3	2
HNSC	RNU7-133P →	+0.413	+5.339	<.001	.003	3	2
LUAD	EXOC7P1 →	+0.021	+5.631	<.001	.004	3	2
BLCA	RN7SL371P →	+0.195	+4.068	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 866 associations by consensus.

RN7SL840P by PRPF18 expression — BLCA

Explore this box plot interactively →