PRPF18

Across TCGA cell cohorts, PRPF18 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,736 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRPF18-associated GO terms across cancer lineages are Double-strand break repair via nonhomologous end joining, Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, and Regulation of tRNA stability. Each is linked with PRPF18 in more than 10 cancer types. Because this analysis shows association rather than direction, both PRPF18-to-partner and partner-to-PRPF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via nonhomologous end joining grouped by PRPF18-low versus PRPF18-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF18→partner) and Y-score (partner→PRPF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.062	+0.682	.001	.002	3	11
BLOOD_Myeloma	Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.163	+1.201	<.001	<.001	3	10
BLOOD_Leukemia	Regulation of tRNA stability →	-0.195	-0.707	<.001	<.001	3	10
BLOOD_Leukemia	tRNA stabilization →	-0.195	-0.707	<.001	<.001	3	10
SKIN	DAMP biosynthetic process →	+0.107	+0.496	<.001	.002	3	10
SKIN	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.107	+0.496	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,736 associations by consensus.

Double-strand break repair via nonhomologous end joining by PRPF18 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →