PROZ

Across TCGA pan-cancer cohorts, PROZ mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PROZ data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PROZ mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PROZ expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where PROZ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.199	0.840	.003	16	view →
CCRCC	OS	Median	All	1.000	0.914	.027	12	view →
GBM	DFS	Median	All	0.271	0.486	.003	12	view →
PDAC	OS	Median	IV	0.836	0.491	.024	7	view →
HNSC	DFS	Tertile	III,IV	1.000	0.911	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PROZ–LUAD (OS)

Open the LUAD breakdown →