PROZ

Across TCGA patient cohorts, PROZ RNA expression is significantly associated with the protein abundance of many other proteins, with 7,530 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PROZ-associated proteins across cancer lineages are SEC63_T537, FADD_S41, and HNRNPM. Each is linked with PROZ in more than 3 cancer types. Because this analysis shows association rather than direction, both PROZ-to-partner and partner-to-PROZ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PROZ versus SEC63_T537 in HNSC, with a Pearson correlation of -0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PROZ→partner) and Y-score (partner→PROZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SEC63_T537 →	-0.893	-0.677	<.001	<.001	3	4
HNSC	FADD_S41 →	-0.670	-0.554	<.001	<.001	3	4
LSCC	HNRNPM →	+0.177	+0.533	<.001	.001	3	4
OV	ZYX_S15 →	-0.652	-0.370	.005	.001	3	3
LSCC	ABLIM3_S576 →	-0.576	-0.365	.003	.007	3	3
CCRCC	UGDH_S476 →	-1.059	-0.320	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,530 associations by consensus.

PROZ vs SEC63_T537 — HNSC

Explore this scatter interactively →