PROZ

Across TCGA patient cohorts, PROZ protein abundance is significantly associated with the RNA expression of many other genes, with 11,542 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PROZ-associated genes across cancer lineages are SERPINE1, AVPR1A, and LYVE1. Each is linked with PROZ in more than 6 cancer types. Because this analysis shows association rather than direction, both PROZ-to-partner and partner-to-PROZ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PROZ versus SERPINE1 in HNSC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROZ→partner) and Y-score (partner→PROZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SERPINE1 →	+1.383	+0.455	<.001	.002	3	7
CCRCC	AVPR1A →	+0.976	+0.412	<.001	.003	3	6
GBM	LYVE1 →	+1.448	+0.454	<.001	<.001	3	6
COAD	MEDAG →	+2.847	+1.411	<.001	.003	3	5
LSCC	CD93 →	+0.892	+0.598	<.001	<.001	3	5
GBM	TREM1 →	+1.514	+0.697	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,542 associations by consensus.

PROZ vs SERPINE1 — HNSC

Explore this scatter interactively →