PROZ

Across TCGA patient cohorts, PROZ mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROZ-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and eEF2. Each is linked with PROZ in more than 1 cancer types. Because this analysis shows association rather than direction, both PROZ-to-partner and partner-to-PROZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PROZ-low versus PROZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROZ→partner) and Y-score (partner→PROZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.151	+3.179	.011	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.941	+3.189	<.001	.010	3	2
UCEC	eEF2 →	+0.386	+2.222	.010	.011	2	2
UCEC	EGFR_pY1068 →	-0.326	-2.906	.002	.001	3	1
UCEC	ERK2 →	+0.245	+3.321	.002	.009	3	1
UCEC	GAPDH →	+0.469	+3.000	.039	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Notch1 by PROZ expression — UCEC

Explore this box plot interactively →