PROZ

Across TCGA cell cohorts, PROZ RNA expression is significantly associated with the go_rna of many other GO terms, with 2,856 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PROZ-associated GO terms across cancer lineages are mRNA splice site recognition, Subtelomeric heterochromatin formation, and Positive regulation of DNA-directed DNA polymerase activity. Each is linked with PROZ in more than 11 cancer types. Because this analysis shows association rather than direction, both PROZ-to-partner and partner-to-PROZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by PROZ-low versus PROZ-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PROZ→partner) and Y-score (partner→PROZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	mRNA splice site recognition →	+0.109	+0.306	.001	.001	3	12
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.111	+0.282	<.001	<.001	3	11
BONE	Positive regulation of DNA-directed DNA polymerase activity →	+0.150	+0.287	.002	.001	3	11
SKIN	DNA integrity checkpoint signaling →	+0.029	+0.223	.003	.002	3	11
SOFT_TISSUE	Pre-mRNA catabolic process →	+0.214	+0.287	<.001	<.001	3	10
LIVER	Mitochondrial tRNA wobble uridine modification →	+0.139	+1.513	<.001	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,856 associations by consensus.

mRNA splice site recognition by PROZ expression — URINARY_TRACT

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