PROZ

Across TCGA cell cohorts, PROZ mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROZ-associated genes across cancer lineages are UNC0642, JAK_8517, and Quizartinib. Each is linked with PROZ in more than 1 cancer types. Because this analysis shows association rather than direction, both PROZ-to-partner and partner-to-PROZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC0642 grouped by PROZ-low versus PROZ-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROZ→partner) and Y-score (partner→PROZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UNC0642 →	+0.238	+2.658	.010	.043	3	1
LARGE_INTESTINE	JAK_8517 →	+0.765	+2.649	.017	.046	3	1
LARGE_INTESTINE	Quizartinib →	+0.375	+2.652	.019	.045	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.619	+2.649	.001	.046	2	1
LARGE_INTESTINE	123829 →	+0.664	+2.649	.022	.046	2	1
LARGE_INTESTINE	729189 →	+0.309	+2.649	.015	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

UNC0642 by PROZ expression — LARGE_INTESTINE

Explore this box plot interactively →