PROX2

Across TCGA patient cohorts, PROX2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROX2-associated genes across cancer lineages are ASNS, GAPDH, and Smac. Each is linked with PROX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROX2-to-partner and partner-to-PROX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PROX2-low versus PROX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROX2→partner) and Y-score (partner→PROX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.468	+2.459	.001	.019	3	2
SKCM	GAPDH →	+0.609	+3.169	.011	.017	3	1
SKCM	Smac →	+0.301	+2.339	.006	.003	3	1
UCEC	EGFR_pY1068 →	-0.301	-3.459	.002	.005	3	1
UCEC	FoxM1 →	+0.220	+1.906	.035	.016	3	1
UCEC	GATA6 →	-0.131	-1.800	.040	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ASNS by PROX2 expression — UCEC

Explore this box plot interactively →