PROX2

Across TCGA cell cohorts, PROX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,237 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PROX2-associated GO terms across cancer lineages are mRNA splice site recognition, Regulation of alternative mRNA splicing, via spliceosome, and Regulation of mRNA splicing, via spliceosome. Each is linked with PROX2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PROX2-to-partner and partner-to-PROX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by PROX2-low versus PROX2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PROX2→partner) and Y-score (partner→PROX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	mRNA splice site recognition →	+0.232	+0.642	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.105	+0.441	<.001	<.001	3	15
OESOPHAGUS	Regulation of mRNA splicing, via spliceosome →	+0.107	+0.460	.003	.002	3	15
OESOPHAGUS	Regulation of myoblast fusion →	+0.124	+0.442	.001	.004	3	14
BONE	Microtubule nucleation →	+0.160	+0.247	<.001	<.001	2	15
UPPER_AERODIGESTIVE_TRACT	mRNA 5'-splice site recognition →	+0.140	+0.601	.001	.001	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,237 associations by consensus.

mRNA splice site recognition by PROX2 expression — OESOPHAGUS

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