PROSER2

Across TCGA patient cohorts, PROSER2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROSER2-associated genes across cancer lineages are SCD, Acetyl-a-Tubulin-Lys40, and MEK1. Each is linked with PROSER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROSER2-to-partner and partner-to-PROSER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCD grouped by PROSER2-low versus PROSER2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROSER2→partner) and Y-score (partner→PROSER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCD →	+0.150	+3.013	.018	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.593	+3.000	.043	.037	2	1
UCEC	MEK1 →	+0.548	+3.000	.009	.036	2	1
UCEC	ASNS →	+0.433	+3.000	.038	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SCD by PROSER2 expression — UCEC

Explore this box plot interactively →