Across TCGA pan-cancer cohorts, PROSER2-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PROSER2-AS1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher PROSER2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PROSER2-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and HNSC show a favorable association.

MESO, HNSC, and KIRP are the cancer types where PROSER2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.444	0.207	.005	67	view →
HNSC	OS	Quartile	All	0.864	0.707	.002	54	view →
KIRP	DFS	Median	II,III,IV	0.478	1.000	.001	52	view →
STAD	DFS	Median	II,III,IV	0.419	0.614	.005	43	view →
UCEC	DFS	Median	All	0.800	0.873	.008	34	view →
CESC	OS	Tertile	IV	0.903	0.401	.010	34	view →
THCA	DFS	Tertile	IV	0.935	0.512	.002	21	view →
KIRC	DFS	Quartile	All	0.737	0.530	.006	18	view →
DLBC	DFS	Median	IV	1.000	0.281	.005	13	view →
THYM	OS	Median	II,III,IV	1.000	0.922	.020	10	view →
ACC	OS	Median	IV	0.799	0.287	.006	9	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: PROSER2-AS1 tumor-vs-normal RNA expression · all PROSER2-AS1 data types