Across TCGA pan-cancer cohorts, PROS1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PROS1 data layer compared with 25 for mass-spec protein and 9 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PROS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PROS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, SARC, and UCEC are the cancer types where PROS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.039	0.928	<.001	24	view →
SARC	DFS	Median	All	0.094	0.611	.001	9	view →
UCEC	DFS	Median	All	0.918	0.609	.015	8	view →
BLCA	OS	Median	All	0.195	0.598	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PROS1 tumor-vs-normal RNA expression · all PROS1 data types