Across TCGA patient cohorts, PROS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,128 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PROS1-associated proteins across cancer lineages are CAVIN1, CAVIN3, and EHD2. Each is linked with PROS1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PROS1-to-partner and partner-to-PROS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PROS1→partner) and Y-score (partner→PROS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CAVIN1 →	+0.945	+0.610	<.001	<.001	3	8
BRCA	CAVIN3 →	+0.780	+1.173	<.001	<.001	3	8
BRCA	EHD2 →	+0.902	+1.031	<.001	<.001	3	8
BRCA	MYO1C →	+0.493	+1.251	<.001	<.001	3	7
UCEC	PARVA →	+0.611	+0.730	<.001	<.001	3	7
UCEC	FLNA →	+0.638	+0.671	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,128 associations by consensus.

Exploration

PROS1 survival (RNA) · tumor vs normal (RNA) · all PROS1 data types