Across TCGA cell cohorts, PROS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,193 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PROS1-associated GO terms across cancer lineages are Endosomal lumen acidification, Positive regulation of translational initiation, and Process utilizing autophagic mechanism. Each is linked with PROS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PROS1-to-partner and partner-to-PROS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PROS1→partner) and Y-score (partner→PROS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Endosomal lumen acidification →	+0.142	+2.327	<.001	<.001	3	11
BLOOD_Myeloma	Positive regulation of translational initiation →	+0.083	+1.168	.003	.007	2	12
KIDNEY	Process utilizing autophagic mechanism →	+0.046	+1.810	.009	.004	3	11
KIDNEY	Autophagy →	+0.046	+1.810	.009	.004	3	11
BLOOD_Leukemia	Heme B biosynthetic process →	+0.127	+1.714	<.001	<.001	3	10
BLOOD_Leukemia	Protoporphyrinogen IX metabolic process →	+0.127	+1.714	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,193 associations by consensus.

Exploration

PROS1 survival (RNA) · tumor vs normal (RNA) · all PROS1 data types