Across TCGA cell cohorts, PROS1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible PROS1-associated genes across cancer lineages are OR2L8, SYT6, and MARCHF11. Each is linked with PROS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROS1-to-partner and partner-to-PROS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROS1→partner) and Y-score (partner→PROS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L8 →	+0.015	+5.266	<.001	.001	3	2
OESOPHAGUS	SYT6 →	+0.317	+3.807	.009	.003	3	1
OESOPHAGUS	MARCHF11 →	+0.209	+3.836	.001	.004	3	1
OESOPHAGUS	PFN3 →	+0.089	+3.392	<.001	.007	3	1
OESOPHAGUS	REM1 →	+0.029	+3.392	.001	.007	3	1
SKIN	KIR2DL3 →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

PROS1 survival (RNA) · tumor vs normal (RNA) · all PROS1 data types