Across TCGA cell cohorts, PRORY RNA expression is significantly associated with the mutation status of many other genes, with 171 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRORY-associated genes across cancer lineages are RIMS2, HECTD2, and POLR2J3. Each is linked with PRORY in more than 1 cancer types. Because this analysis shows association rather than direction, both PRORY-to-partner and partner-to-PRORY results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRORY→partner) and Y-score (partner→PRORY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RIMS2 →	+4.087	+0.257	.009	<.001	3	2
LUNG_NSCLC_LUSC	HECTD2 →	+4.643	+0.536	.008	<.001	3	2
LUNG_NSCLC_LUSC	POLR2J3 →	+4.643	+0.536	.008	<.001	3	2
BLOOD_Leukemia	TMEM132C →	+2.979	+0.056	.007	.005	3	2
SKIN	CDK18 →	+4.273	+0.630	.006	.003	3	2
SKIN	KLHL1 →	+3.103	+0.568	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 171 associations by consensus.

Exploration

PRORY survival (RNA) · tumor vs normal (RNA) · all PRORY data types