PRORP

Across TCGA cell cohorts, PRORP mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRORP-associated genes across cancer lineages are MYH2, OR14C36, and OR2W1. Each is linked with PRORP in more than 1 cancer types. Because this analysis shows association rather than direction, both PRORP-to-partner and partner-to-PRORP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH2 grouped by PRORP-low versus PRORP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRORP→partner) and Y-score (partner→PRORP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYH2 →	+0.029	+5.201	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR14C36 →	+0.015	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR2W1 →	+0.032	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MYH2 by PRORP expression — BLOOD_Leukemia

Explore this box plot interactively →