PROKR2

Across TCGA pan-cancer cohorts, PROKR2 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PROKR2 data layer compared with 17 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher PROKR2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PROKR2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUSC show a favorable association.

OV, UCEC, and PRAD are the cancer types where PROKR2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.245	0.542	.004	18	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
PRAD	DFS	Median	All	0.696	0.935	.002	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
SKCM	OS	Median	II,III,IV	0.945	0.821	.025	4	view →
LUSC	OS	Median	All	0.805	0.391	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PROKR2–OV (DFS)

Open the OV breakdown →