PROKR1

Across TCGA patient cohorts, PROKR1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROKR1-associated genes across cancer lineages are Caspase-7-cleavedD198, Claudin-7, and eEF2K. Each is linked with PROKR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PROKR1-to-partner and partner-to-PROKR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PROKR1-low versus PROKR1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROKR1→partner) and Y-score (partner→PROKR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.968	+3.338	.002	.004	3	3
COAD	Claudin-7 →	+0.601	+3.000	.025	.034	3	2
COAD	eEF2K →	+0.342	+2.008	.014	.018	3	2
UCEC	A-Raf_pS299 →	-0.134	-2.700	.004	.006	3	2
UCEC	Fibronectin →	-0.312	-2.105	.016	.017	3	2
UCEC	Ku80 →	+0.239	+1.884	.009	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Caspase-7-cleavedD198 by PROKR1 expression — COAD

Explore this box plot interactively →