PROKR1

Across TCGA cell cohorts, PROKR1 mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROKR1-associated genes across cancer lineages are BEND2, NCR1, and PON3. Each is linked with PROKR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROKR1-to-partner and partner-to-PROKR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BEND2 grouped by PROKR1-low versus PROKR1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROKR1→partner) and Y-score (partner→PROKR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BEND2 →	+0.010	+4.544	.004	.003	3	1
LUNG_NSCLC_LUAD	NCR1 →	+0.049	+4.212	.005	.007	3	1
SKIN	PON3 →	+0.636	+3.555	<.001	.003	3	1
LARGE_INTESTINE	ULBP1 →	+1.212	+3.364	<.001	.002	3	1
LARGE_INTESTINE	RPF1 →	+0.722	+3.451	<.001	.002	3	1
LARGE_INTESTINE	ATF4 →	+0.767	+3.169	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

BEND2 by PROKR1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →