PROK2

Across TCGA pan-cancer cohorts, PROK2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PROK2 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher PROK2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PROK2 expression acts as an unfavorable survival marker.

LIHC and PRAD are the cancer types where PROK2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.188	0.690	.005	15	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PROK2–LIHC (OS)

Open the LIHC breakdown →