PROK2

Across TCGA patient cohorts, PROK2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROK2-associated genes across cancer lineages are 14-3-3_beta, Heregulin, and Shc_pY317. Each is linked with PROK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROK2-to-partner and partner-to-PROK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PROK2-low versus PROK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROK2→partner) and Y-score (partner→PROK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.121	-2.986	.037	.037	3	1
UCEC	Heregulin →	-0.156	-3.000	.028	.036	3	1
UCEC	Shc_pY317 →	-0.193	-3.000	.027	.037	3	1
UCEC	Di-Ras3 →	-0.229	-3.000	.007	.036	3	1
UCEC	4E-BP1 →	+0.357	+3.000	.022	.037	1	1
UCEC	C-Raf →	+0.212	+3.000	.010	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

14-3-3_beta by PROK2 expression — UCEC

Explore this box plot interactively →