PROK1

Across TCGA patient cohorts, PROK1 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROK1-associated genes across cancer lineages are CD4+ Tcm, Endothelial cells, and Epithelial cells. Each is linked with PROK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROK1-to-partner and partner-to-PROK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tcm grouped by PROK1-low versus PROK1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROK1→partner) and Y-score (partner→PROK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CD4+ Tcm →	+0.014	+6.593	<.001	.020	3	1
UCEC	Endothelial cells →	-0.043	-2.991	.024	.036	3	1
UCEC	Epithelial cells →	-0.097	-2.989	.007	.035	3	1
UCEC	Basophils →	+0.174	+2.321	.041	.036	3	1
UCEC	Mesangial cells →	-0.053	-2.983	.006	.036	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CD4+ Tcm by PROK1 expression — LUSC

Explore this box plot interactively →