PROK1

Across TCGA cell cohorts, PROK1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROK1-associated genes across cancer lineages are TAFA1 and TAS2R41. Each is linked with PROK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROK1-to-partner and partner-to-PROK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by PROK1-low versus PROK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROK1→partner) and Y-score (partner→PROK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAS2R41 →	+0.062	+4.930	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

TAFA1 by PROK1 expression — LARGE_INTESTINE

Explore this box plot interactively →