PRODH2

Across TCGA patient cohorts, PRODH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,937 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PRODH2-associated GO terms across cancer lineages are Cellular ketone metabolic process, Regulation of telomere maintenance in response to DNA damage, and Ribose phosphate biosynthetic process. Each is linked with PRODH2 in more than 10 cancer types. Because this analysis shows association rather than direction, both PRODH2-to-partner and partner-to-PRODH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular ketone metabolic process grouped by PRODH2-low versus PRODH2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRODH2→partner) and Y-score (partner→PRODH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cellular ketone metabolic process →	+0.032	+0.202	<.001	<.001	3	10
STAD	Regulation of telomere maintenance in response to DNA damage →	+0.066	+0.233	<.001	.001	3	10
STAD	Ribose phosphate biosynthetic process →	+0.061	+0.256	<.001	<.001	3	10
STAD	Carbohydrate biosynthetic process →	+0.068	+0.396	<.001	<.001	3	9
STAD	Organic acid catabolic process →	+0.060	+0.389	<.001	<.001	3	9
STAD	Fatty acid beta-oxidation using acyl-CoA dehydrogenase →	+0.074	+0.410	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,937 associations by consensus.

Cellular ketone metabolic process by PRODH2 expression — STAD

Explore this box plot interactively →