PROCR

Across TCGA pan-cancer cohorts, PROCR RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PROCR data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PROCR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PROCR expression acts as an unfavorable survival marker, although some lineages such as MESO and READ show a favorable association.

KIRP, MESO, and READ are the cancer types where PROCR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.829	0.968	<.001	112	view →
MESO	OS	Tertile	All	0.570	0.295	.001	63	view →
READ	DFS	Quartile	III,IV	0.759	0.379	.003	59	view →
LGG	OS	Median	All	0.737	0.878	<.001	52	view →
ACC	OS	Median	II,III,IV	0.632	0.930	.002	44	view →
STAD	OS	Quartile	III,IV	0.340	0.750	.008	33	view →
UVM	DFS	Tertile	All	0.379	0.821	.007	23	view →
GBM	DFS	Quartile	All	0.194	0.361	.003	22	view →
LUAD	DFS	Median	IV	0.745	0.254	.010	20	view →
SARC	DFS	Quartile	All	0.696	0.534	.014	12	view →
UCS	DFS	Tertile	IV	0.338	0.855	.024	12	view →
SCLC	OS	Tertile	II,III,IV	0.288	0.591	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PROCR–KIRP (OS)

Open the KIRP breakdown →