PROCR

Across TCGA pan-cancer cohorts, PROCR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PROCR data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PROCR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PROCR expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where PROCR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.737	0.954	.016	24	view →
UCEC	OS	Quartile	II,III,IV	0.356	1.000	.013	8	view →
HNSC	DFS	Quartile	III,IV	0.787	0.462	.012	6	view →
GBM	OS	Tertile	All	0.343	0.653	.002	6	view →
LSCC	OS	Tertile	All	0.715	1.000	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PROCR–CCRCC (DFS)

Open the CCRCC breakdown →