PROC

Across TCGA pan-cancer cohorts, PROC mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PROC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PROC mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PROC is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and LSCC are the cancer types where PROC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PROC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.093	<.001	12	view →
LUAD	Female	III,IV	−1.303	<.001	9	view →
LSCC	Male	All	−1.215	<.001	8	view →
COAD	All	All	−0.437	.002	6	view →
CCRCC	All	II,III,IV	−0.246	.011	6	view →
OV	All	All	−1.123	.003	2	view →
PDAC	Male	IV	−1.625	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PROC–HNSC

Open the HNSC breakdown →