Across TCGA pan-cancer cohorts, PROB1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PROB1 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PROB1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PROB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, LIHC, and SCLC are the cancer types where PROB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.261	0.798	.006	12	view →
LIHC	DFS	Median	All	0.038	0.553	<.001	12	view →
SCLC	OS	Median	All	0.055	0.653	<.001	6	view →
UCEC	DFS	Median	All	1.000	0.830	.023	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
ESCA	DFS	Median	II,III,IV	0.221	0.527	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: PROB1 tumor-vs-normal RNA expression · all PROB1 data types