Across TCGA pan-cancer cohorts, PROB1 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated PROB1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PROB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PROB1 expression acts as an unfavorable survival marker.

GBM are the cancer types where PROB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.536	0.808	.020	5	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: PROB1 tumor-vs-normal RNA expression · all PROB1 data types