Across TCGA patient cohorts, PROB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,475 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PROB1-associated proteins across cancer lineages are ARHGAP31_S1432, CMBL, and PANK3. Each is linked with PROB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PROB1-to-partner and partner-to-PROB1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PROB1→partner) and Y-score (partner→PROB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP31_S1432 →	-0.744	-0.595	.002	<.001	3	4
BRCA	CMBL →	+0.716	+0.968	<.001	<.001	3	4
PDAC	PANK3 →	+0.464	+0.520	.009	.004	3	4
UCEC	PTPN3_S359 →	+0.642	+0.677	.002	<.001	3	3
OV	YTHDC2 →	+0.360	+0.669	<.001	.003	3	3
PDAC	ARHGAP31 →	-0.253	-0.620	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,475 associations by consensus.

Exploration

PROB1 survival (RNA) · tumor vs normal (RNA) · all PROB1 data types