Across TCGA patient cohorts, PROB1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROB1-associated genes across cancer lineages are eIF4E, ERK2, and GATA6. Each is linked with PROB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROB1-to-partner and partner-to-PROB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROB1→partner) and Y-score (partner→PROB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.182	+3.321	.048	.010	3	2
UCEC	ERK2 →	+0.193	+3.321	.021	.010	3	1
UCEC	GATA6 →	-0.212	-2.985	.004	.034	3	1
UCEC	MSH2 →	-0.294	-2.312	.003	.034	3	1
UCEC	N-Ras →	-0.154	-2.102	.003	.019	3	1
UCEC	PDK1_pS241 →	+0.163	+1.763	.029	.048	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

PROB1 survival (RNA) · tumor vs normal (RNA) · all PROB1 data types