Across TCGA cell cohorts, PROB1 mutation is significantly associated with the RNA expression of many other genes, with 262 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROB1-associated genes across cancer lineages are C16orf78, APOL5, and SMIM23. Each is linked with PROB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROB1-to-partner and partner-to-PROB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROB1→partner) and Y-score (partner→PROB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C16orf78 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Leukemia	APOL5 →	+0.010	+3.475	.007	.006	3	1
BLOOD_Leukemia	SMIM23 →	+0.015	+4.569	<.001	.003	3	1
BLOOD_Leukemia	MORN5 →	+0.273	+4.177	<.001	.001	3	1
LARGE_INTESTINE	CBY1 →	+0.617	+3.299	.002	.004	3	1
LARGE_INTESTINE	USP14 →	+0.754	+3.299	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 262 associations by consensus.

Exploration

PROB1 survival (RNA) · tumor vs normal (RNA) · all PROB1 data types