Across TCGA cell cohorts, PROB1 mutation is significantly associated with the mutation status of many other genes, with 2,917 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROB1-associated genes across cancer lineages are CRACD, ARHGAP33, and CENPT. Each is linked with PROB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PROB1-to-partner and partner-to-PROB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROB1→partner) and Y-score (partner→PROB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CRACD →	+4.502	+5.066	.007	.007	1	5
BLOOD_Lymphoma	ARHGAP33 →	+5.584	+5.014	.003	.003	1	4
BLOOD_Leukemia	CENPT →	+3.963	+4.662	<.001	<.001	1	4
BLOOD_Lymphoma	ISYNA1 →	+5.584	+5.014	.003	.003	1	4
BLOOD_Leukemia	FBXL18 →	+2.478	+3.544	.004	.004	1	4
OVARY	KIF5A →	+3.099	+3.832	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,917 associations by consensus.

Exploration

PROB1 survival (RNA) · tumor vs normal (RNA) · all PROB1 data types