PRNP

Across TCGA pan-cancer cohorts, PRNP Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PRNP data layer compared with 22 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher PRNP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRNP expression acts as an unfavorable survival marker.

KICH, DLBC, and LUSC are the cancer types where PRNP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	9	view →
COAD	OS	Median	All	0.479	0.873	.009	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	III,IV	0.088	0.613	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PRNP–KICH (DFS)

Open the KICH breakdown →