PRNP

Across TCGA pan-cancer cohorts, PRNP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PRNP data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PRNP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRNP expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where PRNP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.310	0.634	.002	23	view →
CCRCC	DFS	Quartile	III,IV	0.140	0.887	.017	11	view →
LSCC	DFS	Median	All	0.603	0.805	.011	9	view →
COAD	DFS	Median	III,IV	0.835	1.000	.033	6	view →
LUAD	DFS	Quartile	All	0.786	0.406	.010	5	view →
HNSC	DFS	Median	II,III,IV	0.986	0.907	.042	3	view →
GBM	DFS	Tertile	All	0.838	0.610	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PRNP–PDAC (DFS)

Open the PDAC breakdown →